The results suggested that the protein levels of TH, P-PI3K, P-AKT and P62 was significantly downregulated in the PD model group compared to that in the control group (p < 0.05 or p < 0.01), and α-syn, Beclin-1 and LC3BII/LCBI were significantly upregulated (p < 0.05 or p < 0.01). Here, AKT1 is linked to Parkinson disease.