According to the RT-PCR test, compared with the PD model group, Cpa4, Lrr1, Tlr9, spc24, Nfkb1, Tnf, Gsta3, Pik3r1 and Esco2 in Galangin group were significantly down-regulated, while Gpc5c was up-regulated. Here, ESCO2 is linked to Parkinson disease.