The qRT-PCR results showed that after treating PD model mice with H-Galangin (100 mg/kg) for 28 days, the mRNA levels of IL-1β, TNF-α, IL-6, SRC, PTGS2 were upregulated except ESR1, GSH-Px and ALB in the mesocerebrum of the PD model mice compared with the control mice (p < 0.05). This evidence concerns the gene PTGS2 and Parkinson disease.