NFKB1 and immune system disorder: Among them, Nfkb1 is a widespread and important transcription factor involved in T cell activation, gene expression involved in a variety of biological functions such as immune regulation and cell adhesion, and is associated with a variety of immune diseases (Camblor et al., 2022; Dange et al., 2015; Ladygina et al., 2013; Jiang et al., 2022).