PIK3R1 and Parkinson disease: Furthermore, the results of differential gene analysis in this study showed that after the intervention of Galangin in PD, the top 10 genes up-regulated in the midbrain of PD mice involving Gsta3, LOC115487393, Pik3r1, Gm40703, Rgs1, Gm52312, Gm46784, Cd200r4, Gprc5c, Gm30657.