In this scoping review, the studies which assessed on DNA polymorphisms, codon 72 and 172 polymorphisms of TP53 gene [23] and homozygous mutant allele of CHI3L1 polymorphism [40] were independent predictors in OSCC [23, 40] and lymph node metastasis of OSCC [40] respectively. This evidence concerns the gene TP53 and metastatic malignant neoplasm in the lymph nodes.