The UCA1 and TUG1 genes showed upregulation in OSCC tumors, respectively. The expression of MALAT1 and H19 was observed to be downregulated in tumor tissues among OSCC patients. MALAT1, showed concordance with the TCGA analysis. HOTAIR expression in OSCC tumors had a positive correlation with tumor volume. A negative correlation was indicated by MALAT1 and H19 with the smokers. Here, TUG1 is linked to neoplasm.