AKT1 and cancer: For instance, the upregulation of pro-apoptotic proteins like BAD can induce apoptosis in cancer cells, highlighting their potential as therapeutic targets.151 Additionally, the phosphorylation of BAD by kinases like Akt can modulate its function and impact cell survival and proliferation in cancer.152 The intricate interplay among regulatory proteins like BCL-2, BAX, and BAD is essential for maintaining cellular homeostasis and determining cell fate under various conditions.