The efficacy of EPO in the management of different diseases such as mastalgia, premenstrual syndrome, atopic eczema, multiple sclerosis, diabetic neuropathy, rheumatoid arthritis, coronary heart disease, gastrointestinal disorders, renal disease, infections, endometriosis, alcoholism, and dementia has been shown (Kerscher and Korting, 1992; Joe and Hart, 1993; Belch and Hill, 2000; Joy et al., 2000; Morse and Clough, 2006; Stuart, 2014; Bamford et al., 2013). The gene discussed is EPO; the disease is mastodynia.