GRIN2B and schizophrenia: Furthermore, other non-specific NMDA antagonists, such as ketamine, and GluN2B-specific antagonists may target extrasynaptic populations of NMDAR to exert rapid-acting antidepressant effects (Miller et al., 2014; Miller et al., 2016; Brown and Gould, 2024; Krystal et al., 2024), although ketamine can also mimic schizophrenia by impairing dlPFC cognitive function (Beck et al., 2020).