TNF and Behcet disease: Enrichment of genes related to ion storage and homeostasis in BD-derived cortical organoids. Store-operated Ca release dysregulated and attenuated in BD cerebral organoids. BD-derived cortical organoids contain lower proportions of neurons and elevated numbers of radial glial cells. Decreased neuron excitability observed in BD-derived cortex organoids but excitability was rescued by treatment with lithium. DEGs between treated and untreated organoids associated with Na + homeostasis and regulation of IL-β and TNF-α.