No alterations were observed in NF1, NF2, or chromosome 22, and no germline mutations were identified. To our knowledge, this is the first report of a hybrid neurofibroma/schwannoma arising from the olfactory groove and the first report employing next-generation sequencing (NGS) for intracranial or nasal HNSTs. Here, NF1 is linked to plexiform neurofibroma.