The search strategy included a combination of MeSH terms and keywords such as "Sodium-Glucose Cotransporter 2 Inhibitors," "SGLT2 inhibitors," "dapagliflozin," "empagliflozin," "Glucagon-Like Peptide-1 Receptor Agonists," "GLP-1 RAs," "semaglutide," "liraglutide," "cardiovascular outcomes," "renal outcomes," and "type 2 diabetes." Boolean operators (AND/OR) were used to combine search terms, and filters were applied to include only English-language articles and studies involving adult populations. The gene discussed is GCG; the disease is type 2 diabetes mellitus.