Clinical exome sequencing identified a heterozygous variant of uncertain significance in two genes: VWF and SERPINE1, the VWF gene is associated with Von Willebrand disease (VWD) types 1 and 3; however, further analysis of Von Willebrand factor (VWF) antigen levels and ristocetin cofactor activity revealed normal results, effectively ruling out VWD. Here, SERPINE1 is linked to von Willebrand disease (hereditary or acquired).