PNLIP and obesity due to melanocortin 4 receptor deficiency: Numerous reports have compiled lists of drugs that exhibit a higher prevalence in association with acute pancreatitis [3]. Orlistat, classified as a tetrahydrolipstatin, is a saturated form derived from lipstatin, and is used for managing obesity. Orlistat is an inhibitor of both gastric and pancreatic lipases, and reduces the absorption of dietary fat and increases fat excretion in feces [4].