Although one case report found prolactin suppression of >90% with initial bromocriptine and later cabergoline treatment in an ESRD patient with severely elevated prolactin levels of 2056 μg/liter [11], there does not appear to be a consistent trend and assurance that dopamine agonism will always severely reduce hyperprolactinemia in CKD or ESRD patients without prolactinomas. This evidence concerns the gene PRL and hyperprolactinemia.