Williams et al. in 2015 noted that about 25% of SDC arise from precedent pleomorphic adenoma as carcinoma ex pleomorphic adenoma and studied the role of viruses like Epstein-Barr virus, cytomegalovirus, and simian virus 40; ionizing radiation involvement; and increased hormone receptor expression in the development of salivary tissue tumors [7]. Here, NR4A1 is linked to carcinoma.