MAPT and early-onset autosomal dominant Alzheimer disease: This is in line with the previous studies that also report changes in PLI values or graph measures limited to the alpha frequency.11,53 Ranasinghe et al.54 state with MEG that excitatory neuronal parameters in the alpha band are associated with increased tau depositions in patients with Alzheimer’s disease, concluding that a net reduction of alpha represents dysregulated network activity.54