Numerous studies have evaluated the link between how tau aggregation is distributed across regions and the interregional connectivity based on rsfMRI.37,48-50 In a group consisting of cognitively intact subjects with or without amyloid positivity and amyloid positive mild cognitive impairment patients, tau deposition in transentorhinal cortex (which corresponds to perirhinal cortex) is associated with reduced rsfMRI connectivity between Brodman area 35 and networks including orbitofrontal/medial prefrontal cortex, as well as posterior hippocampus, parahippocampal gyrus fand angular gyrus. Here, MAPT is linked to Cognitive impairment.