MAPT and early-onset autosomal dominant Alzheimer disease: This tau-related reduced rsfMRI connectivity in cognitively unimpaired individuals is associated with early subtle memory impairment.37 Hrybouski et al. 40 describe a phase of increased rsfMRI connectivity between anterior medial temporal regions in cognitively intact, amyloid positive subjects that is not present in the prodromal Alzheimer’s disease patients.