MAPT and early-onset autosomal dominant Alzheimer disease: Additionally, there was a significant difference in tau PET load in the entorhinal cortex and perirhinal cortex between CU− and prodromal Alzheimer’s disease (both padj < 0.001), in the perirhinal cortex between CU+ and prodromal Alzheimer’s disease (padj = 0.044), but not between CU− and CU+ (Table 2 and Supplementary Table 1).