Interestingly, trehalose was not capable of increasing bladder weight, inducing hyperglycemia, or upregulating the expression of key autophagy proteins (LAMP-1 and Beclin-1) in the bladder, suggesting that the detrimental effects of this disaccharide on bladder tissue are independent of bladder remodeling, hyperglycemia, and the activation of the autophagy process. The gene discussed is BECN1; the disease is Hyperglycemia.