Adenocarcinomas (n = 15) demonstrated reduced or absent expression, and no expression was found in neuroendocrine (n = 2), pseudopapillary (n = 1) or gastrointestinal stromal tumor (n = 1) subtypes, whereas adjacent normal ducts showed high HHLA2 positivity. The gene discussed is HHLA2; the disease is gastrointestinal stromal tumor.