APOE and atherosclerosis: Besides, Han et al. showed that acacetin (0.3–3 μM in vitro; 20 mg/kg in vivo) attenuated hyperglycemia-induced endothelial injury by restoring mitochondrial function through regulation of the Sirt1/AMPK/PGC-1α pathway, thus ameliorating diabetes-stimulated atherosclerosis in ApoE−/− mice (Han et al., 2020).