KCNA5 and atrial fibrillation: Moreover, studies found that acacetin (3–30 μM) could predominantly block SKCa channels expressed in HEK 293 cells, in addition to inhibiting Kv1.5 and Kv4.3 channels, which might also be closely associated with the anti-AF potential of acacetin (Chen et al., 2017; Wu et al., 2011; Wu et al., 2013).