In CML cells, the long non-coding RNA ADORA2A-AS1 upregulates TGFBR1 and ABCC2 expression by adsorbing miR-665, further promoting drug resistance (Guan et al., 2023; Liu et al., 2022). This evidence concerns the gene ADORA2A and chronic myelogenous leukemia, BCR-ABL1 positive.