For example, Qin et al. identified miR-3613-5p as a negative prognostic indicator for hepatocellular carcinoma through a comprehensive analysis of miRNA expression profiles from The Cancer Genome Atlas (TCGA), and KEGG enrichment analysis indicated that it may contribute to tumorigenesis by regulating several signaling pathways, including PI3K/AKT and MAPK(28). This evidence concerns the gene AKT1 and hepatocellular carcinoma.