The Hh/GLI signaling pathway is aberrantly activated in various tumors, including gastric cancer (Qi et al., 2020), lung adenocarcinoma (Li et al., 2016), oral squamous carcinoma (Shimo et al., 2016), breast carcinoma (Hegde et al., 2008), and hepatocellular carcinoma (Yan et al., 2016), and is closely associated with tumorigenesis, progression, invasion, and metastasis. This evidence concerns the gene GLI1 and hepatocellular carcinoma.