In androgen‐sensitive LNCaP and androgen‐insensitive DU145 human prostate carcinoma cells, upregulation of the protein expression of INK4c/p18, INK4a/p16, KIP1/p27, and WAF1/p21, and downmodulation of cdk 2, 4, and 6, cyclin D1, and cyclin E result in programmed cell death. The gene discussed is CDKN1A; the disease is prostate carcinoma.