In mouse models of colorectal tumors, catechin treatment reduced the expression of β‐catenin, cyclooxygenase‐2, IGF‐IR (p‐IGF‐IR), p‐GSK‐3β, and cyclin D1 proteins, resulting in the inhibition of the development of malignant intestinal lesions (Shimizu, Shirakami, Sakai, Adachi, et al., 2008). Here, IGF1R is linked to colorectal neoplasm.