Notably, puerarin significantly enhances muscle mass and function in mice with dexamethasone‐induced sarcopenia, reduces the release of pro‐inflammatory cytokines while promoting the production of anti‐inflammatory factors, lowers oxidative stress, inhibits the expression of muscle apoptosis proteins, and decelerates muscle atrophy development by suppressing the TNF‐α/NF‐κB signaling pathway. This evidence concerns the gene TNF and sarcopenia.