In the multivariate analysis, with results reported as odds ratio (OR) [95% confidence interval (CI)], PTH (1.019, 95% CI: 1.008–1.032]), shape (16.625, 95% CI: 5.922–51.883), and relation with thyroid capsule (3.422, 95% CI: 1.455–9.152) were independent predictive factors associated with the risk of potentially malignant parathyroid diseases (Table 3). This evidence concerns the gene PTH and parathyroid gland disorder.