Even though activation of hCAR does not increase hepatocyte proliferation, rather, a reduced expression of hCAR appears to be related to a worse prognosis for hepatocellular carcinoma; in addition, the human liver carcinoma tissue shows increased DNA methylation in the hCAR promoter and lower hCAR expression, in comparison with adjacent liver tissues (26). This evidence concerns the gene CXADR and hepatocellular carcinoma.