The activation of CAR upregulates the expression of patatin-like phospholipase domain containing protein 3, an emerging marker of liver steatosis, as well as a panel of genes associated with glycolysis and lipogenesis, including Fasn, elongation of long-chain fatty acids family member 6 (Elovl6), stearoyl-CoA desaturase-1(Scd1), and glycerol-3-phosphate acyltransferase (Gpat) (13). Here, NR1I3 is linked to fatty liver disease.