PLOD1 and hypogonadism: Recombinant LH (rLH) has met some challenges in demonstrating benefit in women undergoing ovarian stimulation for IVF/ICSI and in 2000, rLH was registered by EMA in combination with rFSH, for ovarian stimulation in women with severe gonadotrophin deficiency such as hypogonadal hypogonadism (99, 100).