The five genes (Table 2) of the CNL-5-risk model have been rarely investigated in myeloid neoplasms, including PDCD7 (programmed cell death protein 7), CR2 (complement receptor type 2), ZSCAN20 (zinc finger and SCAN domain-containing protein 20), TRIM68 (E3 ubiquitin-protein ligase TRIM68), and LILRA6 (leukocyte immunoglobulin-like receptor subfamily A member 6). The gene discussed is UBE2E3; the disease is myeloid neoplasm.