ERBB2 and neoplasm: All significant univariate variables were applied in a multivariate analysis, which showed that tumor grade [odds ratio (OR), 2.293, 95% confidence interval (CI), 1.340-3.923; P=0.002), HR status (OR, 2.878, 95% CI, 1.677-4.940; P<0.001), HER2 status (OR, 4.861, 95% CI, 2.051-9.382; P<0.001) all exhibited statistically significant associations with pCR occurrence (Table 4).