GPX4 and Myocardial fibrosis: It was observed that after REV-ERBα was knocked out, the disorder of iron metabolism in the myocardium was aggravated, the expression of glutathione peroxidase 4 (GPX4) was decreased, the cardiac function significantly deteriorated in the diabetic mice, and the indicators of myocardial inflammation, myocardial fibrosis, and oxidative stress were significantly increased.