BMAL1 and Disorder of lipid metabolism: To further investigate the role of circadian rhythm disruption in lipid metabolism disorders associated with HF, a study (129) established an HF model and divided it into different groups: normal rhythm (LD), inverted rhythm (DL), a lentiviral vector carrying Bmal1 short hairpin RNA (LV-Bmal1 shRNA), and empty lentiviral vector control (LV-Control shRNA).