Together, the amounts of thyroid stimulating hormone and leptin in the bloodstreamstimulate the enzymes that produce blood sugar, leading to hyperglycemia and dyslipidaemia [29].Among metabolic syndrome patients with and without hypothyroidism, the current investigation discovered a significant increase in serumleptin levels that were positively connected with blood pressure, blood sugar, lipid profile and thyroid stimulating hormone(Figure 1 - see PDF). The gene discussed is LEP; the disease is inherited lipid metabolism disorder.