Patients with metabolic syndrome were more likely to develop cardiovascular illnessesand biomarkers are needed to detect problems in metabolic syndrome Recent research on serum leptin suggests that it may be utilized as amarker to detect problems in people with metabolic syndrome including as T2DM and cardiovascular disease [21].The leptin is mostly found in adipose tissue in amounts proportionate to its bulk. The gene discussed is LEP; the disease is metabolic syndrome.