LGALS9 is a member of the family of galectin, which is widely expressed and involved in immune regulation.[26] Moreover, inhibition of LGALS9 could result in the activation and differentiation of monocytes in sepsis patients.[27] This evidence pointed to a potential role of LGALS9 in monocyte subcluster C5 and suggested that these ligand‐receptor pairs may be implicated in sepsis, while aberrant LGALS9 expression within monocytes may be a potential biomarker for diagnosing sepsis. The gene discussed is LGALS9; the disease is Sepsis.