Then, by intersecting the results from both the LASSO regression analysis and RFE algorithm, we obtained six common genes as the key signature genes for sepsis, including F‐Box Protein 4 (FBXO4), Forkhead Box K1 (FOXK1), MutS Homolog 2 (MSH2), Nop‐7‐associated 2 (NSA2), Transmembrane Protein 128 (TMEM128), and SBDS. This evidence concerns the gene NSA2 and Sepsis.