In adjunction, CAH due to 11β-OHD should be suspected also in young patients with hypokalemic hypertension with low renin and aldosteron levels; in fact, sometimes hypokalemic hypertension could be the first sign in patients, especially with nonclassic CAH form that can have mildly elevated to normal 17-OHP levels, and placed in differential diagnosis with other genetic disorders like apparent mineralocorticoid excess syndrome, Liddle's syndrome, and 17 α-hydroxylase deficiency [10, 11]. Here, REN is linked to congenital adrenal hyperplasia.