PTGS1 is a housekeeping gene that maintains basic prostaglandin levels [52], whereas Prostaglandin E2 (PGE\documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{upgreek}\usepackage{mathrsfs}\setlength{\oddsidemargin}{-69pt}\begin{document}$ {_{2}}$\end{document}) induced by PTGS2 may lead to tumor-promoting inflammatory responses [53]. Here, PTGS1 is linked to neoplasm.