For MS, ROMO1’s diagnostic value was relatively consistent: the training set (GSE21942) had an AUC of 0.910 (95% CI: 0.789-1.000), while the two validation sets (GSE108000 and GSE17048) showed AUCs of 0.723 (95% CI: 0.513–0.934) and 0.720 (95% CI: 0.627–0.812) respectively, indicating moderate diagnostic accuracy for MS(Fig. 5B). The gene discussed is ROMO1; the disease is myeloid sarcoma.