We found 10 overlapping genes in RA (including ROMO1,  CHCHD2,  HDAC6,  DHFR,  FXN,  RHOB,  PKD2,  MAPK9,  SOD2,  SLC25A14), 6 in MS(including ROMO1,  PARK7,  ANXA1,  NUDT2,  SOD1,  KLF2), and 3 in T1D (ROMO1,  CHCHD2,  ANKRD2). This evidence concerns the gene DHFR and rheumatoid arthritis.