The analysis identified six major immune cell populations (T cells CD4+, Monocytes CD16 + HLA-DR+, T cells CD8+, Monocytes CD14 + HLA-DR+, B cells, and NK cells) across four categories: RA, MS, T1D, and HC(Fig. 6A, B, C, D). Here, CD8A is linked to type 1 diabetes mellitus.