Compared to HC, RA samples exhibited significantly lower overall ROMO1 expression (P < 0.001), with notable reductions in T cells CD4+ (P < 0.001), T cells CD8+, Monocytes CD14 + HLA-DR+ (P < 0.001), and NK cells (P < 0.001). The gene discussed is CD8A; the disease is rheumatoid arthritis.