Finally, expanding on these findings, considering the key role of CD14 + HLA-DR + monocytes in antigen presentation and T cell activation, and our results suggesting that ROMO1 may influence CD14 + HLA-DR + monocyte function in the pathogenesis of autoimmune diseases, we especially added supplementary results including integration analysis, cell communication analysis, and two-sample MR analysis to enrich and expand our understanding (Xue et al. 2021; Rigby et al. 1990; Casasola-LaMacchia et al. 2021). This evidence concerns the gene ROMO1 and autoimmune disease.