SH3BP2 and rheumatoid arthritis: Indeed, other studies have shown that, C1M and C3M correlated with DAS28, joint counts and HAQ6 in patients with RA and when treated with methotrexate, changes in biomarker levels of C1M, C3M, C4M and CRPM correlate with change in disease activity after 8 weeks of treatment also in RA patients18.