MRGPRX2 has been associated to various diseases, including asthma,24 allergic rhinitis,34 anaphylaxis, chronic urticaria,35 atopic dermatitis,36 chronic periodontitis,37 idiopathic lung fibrosis,31 and further inflammatory diseases.19 Thus, MRGPRX2 antagonists have great potential as novel drugs for the treatment of those conditions that are associated with a huge medical need. This evidence concerns the gene MRGPRX2 and chronic periodontitis.