Activation of pattern-recognition receptors such as toll-like receptors (TLR), Nucleotide oligomerization domain (NOD)- leucine rich-repeat (LRR) and pyrin domain-containing protein 3 (NLRP3) inflammasome, have been associated with cardiac dysfunction in cecal ligation and puncture (CLP)-induced sepsis models in vivo [12–14]. Here, NLRP3 is linked to Sepsis.