RPGRIP1L and cyst: Line 1 RPGRIP1L mutant kidney organoids were moderately larger than normal isogenic controls (p = 0.0771; Fig. 6a) and had significantly more visible cystic changes (mean cyst number: 0.0538 for wild-type vs 1.846 for RPGRIP1L−/− mutant, Welch’s unpaired t-test p = 0.0194 t = 6.400, df = 2.161, n = 3 biological replicates (organoids derived from the same well of stem cells) each with 31–32 organoids).