SPARC and aneurysm: Through analyzing EndMT-related genes in unruptured aneurysms, ruptured aneurysms, and healthy samples, Jiang et al. revealed that SPARC and FN1 were good predictors of intracranial aneurysms, and that these genes can be used as a screening method for identifying asymptomatic patients with ruptured aneurysms to reduce rupture of the aneurysms [123].