We verified that RNF128 induced the degradation of Beclin1 and subsequent alterations in SLC7A11 and GPX4; however, we failed to fully validate the effect of RNF128 on patient survival at the clinical tissue level and the relationship between factors such as age, sex, TNM stage, tumor metastasis, and the amount of RNF128. Here, GPX4 is linked to neoplasm.