ANXA3 and nonpapillary renal cell carcinoma: Recent studies reveal that ccRCC exhibits an adipocyte-like phenotype characterized by neutral lipid droplet (LD) accumulation, driven by Annexin A3 (AnxA3) isoform switching (reduced 36-kDa/33-kDa ratio), which promotes LD biogenesis via dysregulated vesicular trafficking [100].