CD8A and vulva cancer: Contrasting, Kortekaas et al. demonstrated superior survival rates in vulvar cancer patients with intense t-cell infiltration (e.g., helper T cells defined by CD3 + positivity and CD8 and Foxp3 negativity) regardless of the HPV status when measuring lymphocytes per cells/mm2 in intraepithelial but also stromal compartments within VSCCs [31, 32].