SIRT3 is closely associated with many different kinds of solid tumors (41, 42, 43, 44), given that histone lactylation can activate gene transcription and drive tumorigenesis; we hypothesized that knocking out SIRT3 or reduced SIRT3 activity may lead to increased histone lactylation in cells, thereby affecting tumor progression. This evidence concerns the gene SIRT3 and neoplasm.