TARDBP and amyotrophic lateral sclerosis: TDP-43 mislocalisation has been recapitulated in human induced pluripotent stem cell (hiPSC)-derived spinal cord motor neurons and cortical neurons from mutation carriers of other ALS-associated genes Mislocalisation in the cytoplasm is associated with endoplasmic reticulum stress and impaired autophagy flux82 (appendix page 14).