Different approaches to the histopathological classification of ALS and frontotemporal dementia have been proposed based on these features and include the specific cell type and subcellular localisation of TDP-43 pathology.35,36 At the morphological level, several (non-mutually exclusive) types of TDP-43 aggregates are commonly detected in neuropathological studies, including diffuse granular morphology; compact cytoplasmic inclusions; dot-like structures; thread-like structures; Pick-body-like structures; and granulofilamentous inclusions. This evidence concerns the gene TARDBP and frontotemporal dementia.