Furthermore, TDP-43 pathology can be detected in individuals without ALS or frontotemporal dementia (e.g. in as many as 40% of people older than 65 years; panel 2).42 However, as tools to detect TDP-43 pathology become more sensitive compared to antibody-based methods, further insights have been gleaned. Here, TARDBP is linked to amyotrophic lateral sclerosis.