LEP and obesity due to melanocortin 4 receptor deficiency: Mechanistically, expression of the catalytically active β1 subunit of soluble guanylyl cyclase (sGC-β1), a protective inductor of adipose tissue beiging in obesity,20 was significantly elevated in PVAT of HFD-fed Mpo−/− and Lep−/−Mpo−/− mice (Figures 5G–5J).