In contrast, endothelial dysfunction of Adipoq−/− aortic rings was rescued when incubated with supernatant from Mpo−/− PVAT (Figure 6L, green) and was comparable to WT and Mpo−/− aortic rings incubated with PVAT from WT or Mpo−/− mice, respectively (Figure 6L, violet, brown). Here, MPO is linked to endothelial dysfunction.