Focusing on sialyltransferases, downregulation of ST3GAL5 (the gene that codes for the glycosyltransferase that converts LacCer into GM3) has been linked to increased proliferation, migration and invasion of J82 bladder cancer cells, whereas its overexpression suppressed tumor progression of T24 and 5637 cells [41]. The gene discussed is ST3GAL5; the disease is urinary bladder carcinoma.