The decrease in bone density is most likely a result of hyperlipidemia, which we found previously to reduce skeletal bone density, apparently overriding the anabolic effects of parathyroid hormone (Huang et al., 2008; Li et al., 2014; Parhami et al., 2001; Pirih et al., 2012), which we previously found to be upregulated with exercise (Hsu et al., 2021). This evidence concerns the gene PTH and hyperlipidemia.