POMC and congenital adrenal hyperplasia: In contrast to the aforementioned arguments, in cases of congenital adrenal hyperplasia (CAH) the administration of GC differs, as the aim of the treatment is to replace the cortisol deficiency, while restoring the negative feedback on pituitary adrenocorticotropic hormone (ACTH) to avoid androgen excess at the same time (118, 119).