On evaluating PON1 activity as a prognostic and diagnostic tool in CKD, Samouilidou et al., noticed that PON1 activity may be utilized in the assessment of antioxidant status in both dialyzed and non-dialyzed patients, the prediction of CVD in patients undergoing dialysis and transplantation, the assessment of the antioxidant effect of statins and nutritional supplementation, the assessment of nephropathy occurrence in individuals with T2DM, and the prognosis of future adverse clinical outcomes [64]. This evidence concerns the gene PON1 and type 2 diabetes mellitus.