Through the integration of data from various GEO datasets and TCGA-LIHC dataset, we identified 16 key ICDR&CSRDEGs that were differentially expressed in LIHC: UBE2T, HJURP, PTTG1, CENPA, FOXM1, E2F1, TERT, CDKN2A, CCNA2, SIX1, FOS, SFN, HMGA2, SOX2, RBP2, and DLX2. Our study highlights the pivotal role of ICDR&CSRDEGs in the tumor microenvironment, suggesting their potential as prognostic biomarkers and therapeutic targets. Here, SIX1 is linked to neoplasm.