APOE and Cognitive impairment: As ell, Asle-Rousta et al. (Asle-Rousta et al. 2013) found that fingolimod attenuated cognitive impairment in AD rat model by increasing the activity of PP2 A. Similarly, ApoE mimetic peptide COG1410 improves cognitive impairment in transgenic AD mouse model by activating the activity of PP2 A (Vitek et al. 2012).