LYZ and COVID-19: UMAP embedding of LYZ+ monocytes (Fig. 5e) and nearest neighbor differential abundance analysis showed a significant loss of ncMonos in patients who were convalescing from COVID-19 compared with healthy controls, both in patients who previously suffered mild and severe COVID-19 (Fig. 5f,g), with no significant changes in the average expression per cell of genes related to ncMono and IFN-I gene programs, but rather a reduction in the abundance of cells that expressed these programs (Fig. 5h).