Severe monocytopenia was observed at 1 h after LPS administration (Extended Data Fig. 1c), with CD14+CD16− classic monocytes (cMonos) starting to repopulate the blood ~3 h post-LPS and returning to baseline levels (defined as immediately before the LPS challenge) at ~6 h post-LPS16 (Extended Data Fig. 1c). Here, CD14 is linked to Decreased total monocyte count.